Biocatalysis in the Pharmaceutical and Biotechnology Industries

This book illustrates methods to develop fine chemicals and chiral intermediates used in pharmaceutical, agrochemical, and other biotech applications. International experts detail mechanisms for enzyme-catalyzed modification reactions, analyzing intermediate syntheses for over 60 brand-name pharmaceuticals. They cover instrumentation, solvent selection, and enzyme immobilization techniques and highlight advances to improve yield and discovery, including the use of microbial cells and isolated biocatalysts, gene shuffling, and generation of novel molecules for high-throughput screening. The book contains more than 1000 tables, as well as illustrative drawings and color micrographs.