Chemistry and Pharmacology of Anticancer Drugs

Following a review of cancer causes and progression, current treatments, and the philosophy of drug discovery, this comprehensive work surveys anticancer agents currently in use or in advanced stages of clinical trials, including biological agents. Ideal for those involved in anticancer drug research, the book provides molecular structures for each agent and discusses their history, chemistry, mechanisms of action, structure-function relationships, relevant pharmacology, cytotoxicity, side effects, and formulation issues. It also discusses new research tools, methodologies, tumor-targeting strategies, and the emerging areas of oncogenomics and chemoprevention.