Inhaled Steroids in Asthma

INTRODUCTON
Drug Development of Inhaled Steroids: A Pharmacologist's View Based on Experiences from the Budesonide Project
Ralph Brattsand

Part Two USE OF INHALED STEROIDS
How Inhaled Corticosteroids Changed Asthma Therapy
William W. Busse
Side Effects of Inhaled Corticosteroids
Paul M. O'Byrne and Dilini Vethanayagam

Part Three MOLECULAR ASPECTS OF STEROID ACTION
Mechanisms of Gene Regulation by the Glucocorticoid Receptor
Gary B. Faulds, Nanthakumar Subramaniam, Johan Lidén, and Sam Okret
Relationship of Dose- and Time-Dependent Corticosteroid Responses to Receptor Turnover
William J. Jusko
Blockade of Chemokine Production/Function as an Example of Glucocorticoid Anti-inflammatory Actions
Cristiana Stellato
Newly Recognized Glucocorticoid Targets
Nicola M. Heller and Robert P. Schleimer

Part Four DETERMINANT S OF AIRWAY-LUNG SELECTIVITY
Aerosol Delivery Devices and Airways/Lung Deposition
Myrna B. Dolovich
Uptake, Retention, and Biotransformation of Corticosteroids in the Lung and Airways
Staffan Edsbäcker
Systemic Disposition and Effects of Inhaled Corticosteroids
Hartmut Derendorf, Sriram Krishnaswami, Gunther Hochhaus, and Helmut Möllmann
Extrapulmonary Effects of Inhaled Corticosteroids
Judah A. Denburg, Mark D. Inman, Roma Sehmi, Lorna J. Wood, Gail M. Gauvreau, and Paul M. O'Byrne
Factors Involved in the Pulmonary Targeting of Inhaled Glucocorticoids: The Use of Pharmacokinetic/Dynamic Simulations
Gunther Hochhaus, Hartmut Derendorf, Helmut Möllmann, and James Talton
Reversible Glucocorticoid Esterification
Magnus Jendbro and Carl-Johan Johansson

Part Five AIRWAY-LUNG SELECTIVITY OF CURRENT INHALED STEROIDS
Airway Selectivity of Current Inhaled Corticosteroids in Properly Designed Studies
J. Paul Seale and Paul M. O'Byrne
Childhood Asthma and Growth
Søren Pedersen
Evaluation and Comparison of Inhaled Steroids
Stanley J. Szefler and Rich